ABSTRACT
Objective:To explore the therapeutic effect of sodium hyaluronate combined with glucosamine sulfate in the treatment of knee osteoarthritis.Methods:A total of 90 outpatients and inpatients with knee osteoarthritis who visited the Department of Orthopedics and Traumatology, Daishan County Hospital of Traditional Chinese Medicine from January to June 2020 were selected, and they were divided into sodium hyaluronate group (control group) and sodium hyaluronate combined with glucosamine sulfate group (observation group) by random number table method, with 45 patients in each group. Visual analog scale (VAS) score was used to evaluate the changes of pain in the two groups before treatment, 5 weeks and 6 months after treatment, respectively; at the same time, the total effective rate of 5 weeks and 6 months after treatment was compared between the two groups.Results:Before treatment, there was no significant difference in VAS scores [(7.4 ± 1.5) vs (7.3 ± 1.7) points] between the two groups ( t = 0.24, P = 0.812); at 5 weeks [(5.3 ± 1.1) vs (4.1 ± 1.2) points] and 6 months after treatment [(4.0 ± 0.8) vs (3.2 ± 0.9) points], the VAS scores of the observation group were significantly lower than those of the control group, and the differences were statistically significant ( t = 5.54, 5.32, P < 0.001). Compared with the same group before treatment, VAS scores were lower in the two groups at 5 weeks and 6 months after treatment, and the differences were statistically significant ( P < 0.05). At 5 weeks after treatment, there was no significant difference in the total effective rates [44.4% (20/45) vs 48.9% (22/45)] between the two groups (χ 2 = 0.18, P = 0.672); at 6 months after treatment, the total effective rate of the observation group (91.1%, 41/45) was significantly higher than that of the control group (66.7%, 30/45), and the difference was statistically significant (χ 2 = 8.07, P = 0.004). Conclusion:Sodium hyaluronate combined with glucosamine sulfate can significantly reduce the pain in patients with knee osteoarthritis, the total effective rate is higher, and is better than the effect of sodium hyaluronate alone.
ABSTRACT
Objective To evaluate the effect of open reduction and internal fixation in the treatment of 50 patients with tibial plateau fractures(FTP),and its influence on knee functional recovery.Methods 50 patients with FTP were treated with open reduction and internal fixation.The operation time,blood loss,gypsum braking time,hospitalization time and fracture healing time were recorded,and the incidence of complication was analyzed as well.3 days after operation,imaging evaluation was performed to evaluate the effect of operation reduction.The patients were followed up for 6 months.The HSS scores before and after operation were compared,and the clinical efficacy was evaluated by HSS score.Results 50 FTP patients treatment with internal fixation were successful.The operation time was (101.36±15.63)min,the blood loss was (291.45±34.98)mL,the hospitalization time was (6.85±1.21)d,the postoperative plaster brake time was (20.35±3.67)d,the fracture healing time was (87.63±2.36)d.50 patients were all satisfied to reset,excellent reduction in 40 cases,good reduction in 7 cases,satisfaction in 3 cases,postoperative incision infection in 2 cases,pulmonary embolism in 1 case,nonunion in 1 case and fascia compartment syndrome in 1 case,the total incidence rate of complications was 10.0%.6 months after operation,the HSS scores(pain,function,range of motion,muscle strength,flexion deformity,joint stability) were significantly higher than before operation(t=12.070,17.241,19.986,10.850,21.098,10.238,all P=0.000).Of 50 cases with FTP,excellent in 23 cases,good in 19 cases,fair in 7 cases and poor in 1 case,the excellent and good rate was 84.0%.Conclusion Open reduction and internal fixation in the treatment of FTP gets satisfactory reduction effect,it has certain safety,and it can effectively promote fracture healing and knee functional recovery and improvement,its clinical effect is remarkable.